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  • Title: Evaluation of new approaches to poliovirus vaccine neurovirulence tests.
    Author: Wood DJ.
    Journal: Dev Biol Stand; 1996; 86():79-83. PubMed ID: 8785995.
    Abstract:
    Transgenic mice that express the human receptor for poliovirus and mutant analysis by PCR followed by restriction enzyme cleavage (MAPREC) are two new approaches to poliovirus vaccine neurovirulence testing. This review assesses the validity and current status of these tests. Both approaches require further rigorous validation and development. They are most likely to be used as corollary rather than replacement tests for the current neurovirulence tests.
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