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  • Title: Effect of gonadal steroids on bone and other physiological parameters of male broiler chickens.
    Author: Rath NC, Huff WE, Balog JM, Bayyari GR.
    Journal: Poult Sci; 1996 Apr; 75(4):556-62. PubMed ID: 8786949.
    Abstract:
    Comparative studies of the effects of estradiol, progesterone, testosterone, cholesterol, and megestrol on juvenile chickens were carried out to determine their effects on bone and other physiological parameters. The chickens were implanted at 6 wk of age with ethylene-vinyl acetate copolymers containing steroids equivalent to a weekly dose of 10 mg/kg body weight for 3 consecutive wk. Estradiol caused a gain in body weight and relative liver weight but suppressed the growth of comb and testis. It also increased several serum variables, including triglycerides, cholesterol, calcium, phosphorus, and iron, and reduced testosterone levels. Testosterone produced an increase in comb weight and decreased both testicular and bursal weights. Growths of testis and comb were suppressed in progesterone-implanted chickens, as was the level of serum testosterone. Megestrol stimulated liver growth and increased serum testosterone levels. The lengths, relative weights, diaphyseal diameters, and ash percentages of both femur and tibia did not change significantly due to any treatment except that estradiol reduced tibial weight. Both progesterone and megestrol increased fibular growth plate alkaline and tartarate-resistant acid phosphatase activities. Other steroids did not affect these or the levels of calcium and of phosphorus of the fibular growth plate. Only testosterone caused a marked increase in the breaking strengths of both femur and tibia in all three parameters, i.e. load at yield, Young's modulus, and stress at yield responses. These findings suggest that the effects of steroids on bone in juvenile chickens may be limited.
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