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  • Title: [Regulation of liver carbohydrate and lipid metabolism by cell volume].
    Author: Hue L.
    Journal: Ann Endocrinol (Paris); 1995; 56(6):599-601. PubMed ID: 8787351.
    Abstract:
    Certain amino acids such as glutamine and proline stimulate liver glycogen synthesis and lipogenesis. This implies cell swelling and leads to the activation of glycogen synthase and acetyl-CoA carboxylase by a common mechanism. This mechanism results from the cell response to swelling and involves a fall in intracellular concentration of chloride ions and an increase in intracellular concentration of glutamate and aspartate. These ions indeed regulate the protein phosphatases that activate glycogen synthase and acetyl-CoA carboxylase.
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