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  • Title: Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease.
    Author: Almasy L, Tierney C, Risch N.
    Journal: Genet Epidemiol; 1995; 12(6):565-70. PubMed ID: 8787974.
    Abstract:
    Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed.
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