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  • Title: Determination of schizandrin in human plasma by gas chromatography-mass spectrometry.
    Author: Ono H, Matsuzaki Y, Wakui Y, Takeda S, Ikeya Y, Amagaya S, Maruno M.
    Journal: J Chromatogr B Biomed Appl; 1995 Dec 15; 674(2):293-7. PubMed ID: 8788159.
    Abstract:
    Schizandrin (SZ) is one of the lignan components from Schisandra fruits. A highly sensitive and precise method for the determination of SZ in human plasma was developed involving selected-ion monitoring with gas chromatography-mass spectrometry using a fused-silica capillary column. A 0.1-ml plasma sample was used for solid-phase extraction. A good linear relationship was obtained in the concentration range studied (2.0-500 ng/ml) and the method was sufficiently accurate and precise to support clinical pharmacokinetic studies. After oral administration of SZ at a dose of 15 mg to healthy male subjects, the average value of the maximum plasma concentration of SZ was 96.1 +/- 14.1 ng/ml. The plasma concentration of this substance could be monitored for 8 h after administration.
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