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  • Title: Clinical evaluation of antineutrophil cytoplasmic autoantibodies in ANCA-associated diseases.
    Author: Cristea A, Badea T, Bodizs G, Olinic N.
    Journal: J Clin Lab Immunol; 1995; 46(2):85-94. PubMed ID: 8789131.
    Abstract:
    Antineutrophil cytoplasmic autoantibodies have been performed in 110 patients referred to the laboratory as a presumptive systemic vasculitis, idiopathic crescentic glomerulonephritis, inflammatory bowel disease or SLE with vascular manifestation. 25 patients were found to be positive with c-, or p-ANCA patterns in indirect immunofluorescent test. We describe several cases in which histological confirmation is not available, an early consideration of a positive ANCA test may offer a reliable diagnosis and effective therapeutic handling, while the cases when the test was not considered, the occurence of relapse was inevitable.
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