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  • Title: Disease mechanism: unravelling Wiskott-Aldrich syndrome.
    Author: Kirchhausen T, Rosen FS.
    Journal: Curr Biol; 1996 Jun 01; 6(6):676-8. PubMed ID: 8793292.
    Abstract:
    The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.
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