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  • Title: Maxi-K+ channel in plasma membrane of basal cells dissociated from the stria vascularis of gerbils.
    Author: Takeuchi S, Irimajiri A.
    Journal: Hear Res; 1996 May; 95(1-2):18-25. PubMed ID: 8793504.
    Abstract:
    The plasma membrane of isolated strial basal cells has been probed for conductive pathways by the patch-clamp single-channel recording technique. Maxi-K+ channels were identified in 28 excised patches (i.e., 29%) out of 95, and these active patches each contained an average of 2.4 channel activities. In the cell-attached mode, activity of the maxi-K+ channel was also observed. Properties of the maxi-K+ channel thus revealed include: (1) linear I-V relations with 150 mM K+ on both sides of the membrane, (2) a unit conductance of 246.2 +/- 4.0 pS (n = 14). (3) Ca2- sensitivity, (4) activation by membrane depolarization. (5) a complete block by Ba2- (2 mM) from either side of the membrane. (6) a flickering block by quinine (0.1 mM) or verapamil (0.1 mM) from either side of the membrane, and (7) a complete block by tetraethylammonium (1 mM) from the outside only. The maxi-K+ channel may play a role in the generation of endocochlear potentials.
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