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  • Title: No influence of pantoprazole on the pharmacokinetics of phenytoin.
    Author: Middle MV, Müller FO, Schall R, Groenewoud G, Hundt HK, Huber R, Bliesath H, Steinijans VW.
    Journal: Int J Clin Pharmacol Ther; 1996 May; 34(1 Suppl):S72-5. PubMed ID: 8793606.
    Abstract:
    Twenty-three healthy, male volunteers completed this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 days. In addition, a single-dose of 300 mg (3 x 100 mg capsules) phenytoin sodium was administered on day 4 of each treatment period. A 14-day wash-out period was allowed between phenytoin administrations. The results indicate that pantoprazole neither affects the rate nor the extent of absorption, nor the elimination of phenytoin.
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