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  • Title: Inhibition of lipid peroxidation by sesquiterpenoid in Heterotheca inuloides.
    Author: Haraguchi H, Saito T, Ishikawa H, Sanchez Y, Ogura T, Kubo I.
    Journal: J Pharm Pharmacol; 1996 Apr; 48(4):441-3. PubMed ID: 8794999.
    Abstract:
    A sesquiterpenoid, 7-hydroxy-3,4-dihydrocadalin, isolated from a Mexican medicinal plant Heterotheca inuloides was evaluated as an antioxidant. This sesquiterpenoid inhibited mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH. Furthermore, 7-hydroxy-3,4-dihydrocadalin protected red cells against oxidative haemolysis. This sesquiterpene was thus shown to be effective in protecting biological systems against oxidative stresses.
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