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  • Title: Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans.
    Author: Zhang D, Hansen EB, Deck J, Heinze TM, Sutherland JB, Cerniglia CE.
    Journal: Appl Environ Microbiol; 1996 Sep; 62(9):3477-9. PubMed ID: 8795241.
    Abstract:
    The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyazatadine, were isolated by high-performance liquid chromatography and characterized by mass spectrometric and proton nuclear magnetic resonance spectroscopic analyses.
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