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  • Title: International, collaborative experience of 1789 patients having multifetal pregnancy reduction: a plateauing of risks and outcomes.
    Author: Evans MI, Dommergues M, Wapner RJ, Goldberg JD, Lynch L, Zador IE, Carpenter RJ, Timor-Tritsch I, Brambati B, Nicolaides KH, Dumez Y, Monteagudo A, Johnson MP, Golbus MS, Tului L, Polak SM, Berkowitz RL.
    Journal: J Soc Gynecol Investig; 1996; 3(1):23-6. PubMed ID: 8796803.
    Abstract:
    OBJECTIVE: To develop the most up-to-date, complete data base of multifetal pregnancy reduction (MFPR) from cases, and to provide the best counseling for couples with multifetal pregnancies. METHODS: From nine centers in five countries, 1789 completed MFPR cases were collected and outcomes evaluated. Pregnancy losses were defined as through 24 weeks and deliveries categorized in groups of 25-28, 29-32, 33-36, and 37 or more weeks. RESULTS: Overall, the pregnancy loss rate was 11.7% but varied from a low of 7.6% for triplets to twins and increased with each additional starting number to 22.9% for sextuplets or higher. Early premature deliveries (25-28 weeks) were 4.5% and varied with starting number. Loss rates by finishing number were highest for triplets and lowest for twins, but gestational age at delivery was highest for singletons. CONCLUSIONS: Multifetal pregnancy reduction has been shown to be a safe and effective method to improve outcome in multifetal pregnancies. Outcomes are worse with higher-order gestations and support the need for continued vigilance of fertility therapy.
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