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  • Title: Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol.
    Author: Berendt RF, Walker JS, Dominik JW, Stephen EL.
    Journal: Antimicrob Agents Chemother; 1977 Jun; 11(6):1069-70. PubMed ID: 879752.
    Abstract:
    The effects of graded doses of ribavirin administered either by aerosol or intraperitoneally were compared in influenza virus-infected mice. The median effective dose values (based upon percent survival) were 3.3 and 15.8 mg/kg per day for the aerosol and intraperitoneal routes, respectively. Lung lesion scores and titer of virus were lower after aerosol than intraperitoneal therapy.
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