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  • Title: High-performance liquid chromatographic assay for the separation and characterization of metabolites of the potential cytostatic drug oracine.
    Author: Wsól V, Kvasnicková E, Szotáková B, Hais IM.
    Journal: J Chromatogr B Biomed Appl; 1996 May 31; 681(1):169-75. PubMed ID: 8798926.
    Abstract:
    Oracine (I), a potential cytostatic drug, is enzymically converted to a number of metabolites whose formation has been studied in vitro and in vivo. The metabolites were separated by reversed-phase HPLC and characterized by UV spectra. Preparative TLC served for the isolation of the individual metabolites to allow their identification. Two metabolites were identified by Fourier transform NMR as 11-dihydrooracine (II) and a phenolic product (III). Two further metabolites (IV,V) were characterized. Some minor, presumably 11-dihydro metabolites and an 11-oxo metabolite produced in vitro and in vivo were revealed.
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