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  • Title: Circulating soluble intercellular adhesion molecule-1 in type C viral hepatitis.
    Author: Yang SS, Tsai G, Wu CH, Chen DS.
    Journal: Hepatogastroenterology; 1996; 43(9):575-81. PubMed ID: 8799398.
    Abstract:
    BACKGROUND/AIMS: Intercellular adhesion molecule-1 (ICAM-1) is one of the members of the immunoglobulin supergene family; it expresses in response to inflammatory mediators and activation. Circulating soluble ICAM-1 (sICAM-1) levels in acute and chronic viral hepatitis C virus infection were studied. MATERIALS AND METHODS: Thirty blood samples from 10 patients with acute hepatitis C, and 36 blood samples from 25 patients with chronic hepatitis C were compared with those from 10 healthy volunteers, using the enzyme immunoassay method. RESULTS: The mean circulating sICAM-1 activities in healthy volunteers was 339 +/- 93 ng/ml. Maximum values of sICAM-1 activities in acute (1394 +/- 502 ng/ml, P = 0.004) and chronic (662 +/- 477 ng/ml, P = 0.047) hepatitis C were increased. Acute hepatitis had a higher maximum circulating sICAM-1 activity than chronic hepatitis (P = 0.009). Longitudinal circulating sICAM-1 activities roughly correlated with the serum aminotransferase (ALT) activities. In acute viral hepatitis C, three patients developed an increase in circulating sICAM-1 activities before the manifestation of abnormal ALT activity. Circulating sICAM-1 activities showed a positive correlation with serum ALT activities (P < 0.001) and serum total bilirubin levels (P = 0.001) and a negative correlation with serum albumin levels (P = 0.01). CONCLUSIONS: The present study suggested that ICAM-1 plays a role in the hepatocellular injury during viral hepatitis C infection.
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