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  • Title: Model studies in tumor incidence.
    Author: Popp FA.
    Journal: Arch Geschwulstforsch; 1977; 47(2):106-8. PubMed ID: 879979.
    Abstract:
    Two models of tumor incidence predicting the latency period as a function of the applied dose of a carcinogenic compound yield the same relationship as it has been empirically stated by Bryan and Shimkin (1,2). One model is based on a single-cell damage, the other one on a disturbtion of proliferation control within the cell population. The observed latency periods compared to the predicted values show that the tommunication model is a better basis for understanding chemical carcinogenesis than the single cell incidence.
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