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  • Title: Regulation of growth and DNA synthesis in mouse lymphoma L5178Y cells under conditions of nutrient depletion.
    Author: Malec J, Kornacka L, Sawecka J.
    Journal: Arch Immunol Ther Exp (Warsz); 1977; 25(1):149-55. PubMed ID: 879995.
    Abstract:
    The effect of cultivation of L5178Y lymphoblasts to high density and in two kinds of nutrient-depleted medium on their growth was observed. It was found that in cell population grown to stationary phase the mitotic index and labeled thymidine incorporation dropped about 3 times in comparison with exponential control. Upon dilution with fresh medium the cells resume traverse the life cycle in partially synchronized manner. Cultivation of the cells in medium with 0-5% serum induced very rapid loss of their viability. Cultivation of the cells in medium without asparagine and with dialyzed serum caused significant slowing of their growth-rate and upon dilution with complete medium the cells entered the exponential rate of division in an asynchronous manner.
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