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  • Title: Endopap-versus Pipelle-sampling in the diagnosis of postmenopausal endometrial disease.
    Author: Van den Bosch T, Vandendael A, Wranz PA, Lombard CJ.
    Journal: Eur J Obstet Gynecol Reprod Biol; 1996 Jan; 64(1):91-4. PubMed ID: 8801158.
    Abstract:
    OBJECTIVE: To evaluate the accuracy of Endopap- and Pipelle-sampling in the diagnosis of postmenopausal disease. STUDY DESIGN: Observational study in the setting of a University Hospital. One hundred and six consecutive postmenopausal women presenting with uterine bleeding or endometrial cells on cervical cytology underwent an Endopap sampling as well as a Pipelle biopsy. Thereafter, 89 of those women underwent a hysteroscopy and curettage (n = 71) or a hysterectomy (n = 18). The diagnostic accuracy of Pipelle and Endopap was assessed against the final diagnosis. RESULTS: Endometrial carcinoma was found in five cases (6%), benign disease in 34 (38%). The sensitivity of Endopap and Pipelle for the detection of endometrial disease was 56 and 51%, respectively, with a specificity of 94 and 100%, respectively. The sensitivity for endometrial carcinoma was 80% for Endopap and 100% for Pipelle. CONCLUSIONS: Our data tend to favor Pipelle against Endopap as diagnostic tool in endometrial disease in symptomatic postmenopausal women.
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