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  • Title: Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.
    Author: Joseph-Horne T, Loeffler RS, Hollomon DW, Kelly SL.
    Journal: J Med Vet Mycol; 1996; 34(3):223-5. PubMed ID: 8803806.
    Abstract:
    Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.
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