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  • Title: The postembryonic development of somatostatin immunoreactivity in the central posterior/prepacemaker nucleus of weakly electric fish, Apteronotus leptorhynchus: a double-labelling study.
    Author: Stroh T, Zupanc GK.
    Journal: Brain Res Dev Brain Res; 1996 May 31; 93(1-2):76-87. PubMed ID: 8804694.
    Abstract:
    The neuropeptide somatostatin (SS) is widely distributed in both the central and peripheral nervous system of vertebrates. Its widespread distribution is paralleled by a large variety of diverse functions. While embryonic and perinatal development of SS-like immunoreactivity have been well examined, little is known about the postnatal development of this neuropeptide. Since, in teleosts, neurogenesis persists in many brain regions during adulthood, these vertebrates are well suited to investigate this phenomenon. In the present study, we have, therefore, examined the development of somatostatinergic cells born during adulthood in the central posterior/prepacemaker nucleus (CP/PPn) of Apteronotus leptorhynchus, a weakly electric gymnotiform fish. This was achieved by labelling proliferating cells with the thymidine analogue 5-bromo-2'-deoxyuridine (BrdU) and by simultaneous immunocytochemical detection of SS-like immunoreactivity. SS-like immunoreactivity is adopted in a period between 2 days and 3.5 days after birth. While the number of BrdU-labelled cells in the CP/PPn decreases 10 days after birth, the percentage of double-labelled cells among the BrdU-labelled cells remains with 1.0-7.6% in the period between 3.5 days and 100 days after birth rather constant. This percentage matches well the fraction of SS-positive cells in the total population of cells present in the CP/PPn.
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