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  • Title: The E5 gene of HPV-16 enhances keratinocyte immortalization by full-length DNA.
    Author: Stöppler MC, Straight SW, Tsao G, Schlegel R, McCance DJ.
    Journal: Virology; 1996 Sep 01; 223(1):251-4. PubMed ID: 8806560.
    Abstract:
    Human papillomavirus type 16 (HPV-16) is the most common papillomavirus genome found in human cervical cancers and its DNA is capable of immortalizing primary keratinocytes in vitro. When expressed by their native promoter, two separate HPV-16 oncogenes, E6 and E7, cooperate to immortalize primary human keratinocytes. Early HPV cervical lesions express abundant amounts of E5-specific RNA, and using a quantitative keratinocyte immortalization assay, we demonstrate here that E5 can act in cis to increase (4-10 fold) the efficiency of cellular immortalization by E6/E7. These results suggest that the expression of the HPV-16 E5 gene may play a role in the pathogenesis of early HPV infections by potentiating the effects of E6/E7.
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