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  • Title: Anti-HIV activity of multibranched peptide constructs derived either from the cleavage sequence or from the transmembrane domain (gp41) of the human immunodeficiency virus type 1 envelope.
    Author: Sabatier JM, Mabrouk K, Moulard M, Rochat H, Van Rietschoten J, Fenouillet E.
    Journal: Virology; 1996 Sep 15; 223(2):406-8. PubMed ID: 8806580.
    Abstract:
    Multibranched peptides (SPCs) derived either from the fusion protein (gp41) sequence or from the cleavage sequence of the human immunodeficiency virus type 1 envelope were chemically synthesized and tested for their ability to inhibit both syncytium formation and HIV production in CD4+ cells. The gp41-derived SPCs had no effect. In contrast, an SPC encompassing the envelope cleavage sites strongly inhibited both HIV Env-induced syncytium formation and viral production.
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