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  • Title: The effect of various steroids on corpus luteum function.
    Author: Hooley RD, Williams DM, Findlay JK.
    Journal: Contraception; 1977 Jan; 15(1):53-64. PubMed ID: 880803.
    Abstract:
    The effect of various steroids on corpus luteum function was investigated. The effect of d-norgestrel, R-5020, norethindrone, equilenin, megestrol acetate, estriol, and R-2323 was assessed by the effect on the progesterone secretion rate of the autotransplanted ovary of the ewe. Sheep with cervical ovarian autotransplants were used to facilitate infusion of the test compound directly into the arterial supply of the ovary and to allow progesterone secretion rates to be determined. Only 100mcg d-norgestrel/hour for 8 hours and 100 mcg R-5020/hour for 8 hours markedly suppressed progesterone ouput from the ovary.
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