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  • Title: Cellulose acetate butyrate microparticles for controlled release of carbamazepine.
    Author: Arnaud P, Boué C, Chaumeil JC.
    Journal: J Microencapsul; 1996; 13(4):407-17. PubMed ID: 8808778.
    Abstract:
    Cellulose acetate butyrate microparticles loaded in carbamazepine were prepared by a solvent evaporation technique. A decrease of the amount of organic solvent (from 80 to 40 ml of methylene chloride) increased the microparticle average diameter (73-111 and 207 microns) and decreased the carbamazepine release rate (T50% increased from 3.3 to 16.8 and 166.4 min). The microparticle area under the curve at 120 min was similar to that obtained with Tegretol LP 200 tablets.
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