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  • Title: The regulation of retinoic acid formation.
    Author: Wolf G.
    Journal: Nutr Rev; 1996 Jun; 54(6):182-4. PubMed ID: 8810827.
    Abstract:
    Rat liver microsomal as well as cytosolic retinol dehydrogenases from cellular retinal-binding protein (CRBP)-retinal from CRBP-retinol. A cytosolic dehydrogenase transforms retinal into retinoic acid. Apo-CRBP and ethanol inhibit the cytosolic but not the microsomal retinol dehydrogenase, the latter being the primary enzyme in the rate-limiting step in retinoic acid synthesis.
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