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  • Title: Lordosis: inhibiting effects progesterone in the female rat.
    Author: Marrone BL, Rodriguez-Sierra JF, Feder HH.
    Journal: Horm Behav; 1977 Jun; 8(3):391-402. PubMed ID: 881174.
    Abstract:
    The effectiveness of progesterone (P) in inhibiting sexual behavior in the rat was tested. 2 doses of P were used .5 and 5.0 mg. In the 1st experiment, ovariectomized rats were given either dose of P 1 hour before receiving a 5 mcg/kg dose of estradiol benzoate (EB). 44 hours later sexual behavior was tested. .5 mg P was then given and sexual behavior retested. 5 mg prior to the start of estrogen conditioning inhibited the facilitatory effects on lordosis of a 2nd injection of P 44 hours after EB. This was exhibited only for the high dosage. In a 2nd experiment, ovariectomized rats received 5 mcg EB and were pretested for sexual behavior 44 hours later. Animals then received P at 1 of 2 doses and were tested for sexual behavior 4 hours later. After 20 hours, sexual behavior was again tested; animals received .5 mg P and were retested. Both the high and low dose facilitated lordosis 44 hours after EB. 4 hours after the 2nd injection both groups were inhibited. Finally, ovariectomized rats were pretested for sexual behavior as in the 2nd experiment and injected with 5 mg of P, tested for sexual behavior 4 hours later, and retested 20 hours after that. Animals then either received a control injection or .5 mg P and tested 4 hours later. Animals were facilitated by the high dose. However, the 2nd dose depressed sexual activity. Results in the first 2 experiments indicate that the rat has 2 types of inhibitory actions on sexual behavior. The dose required to produce sequential inhibition in rats is lower than the dose required to produce concurrent inhibition.
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