These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Recovery of chorda tympani nerve function following injury.
    Author: Cain P, Frank ME, Barry MA.
    Journal: Exp Neurol; 1996 Oct; 141(2):337-46. PubMed ID: 8812170.
    Abstract:
    The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani nerve was crushed in the middle ear and the animals were allowed to survive from 2 to 16 weeks. At 2 weeks, CT fibers had degenerated distal to the crush site. Up to 16 weeks after crush, there were 67% fewer myelinated fibers in regenerated nerves than in controls. The mean area of the Ca(2+)-ATPase-stained core of the fungiform taste buds was significantly smaller than in controls 2 weeks after injury, but recovered to control values by 4 weeks. Electrophysiological responses to taste stimuli were recorded from the chorda tympani distal to the injury. No responses were seen after 2 weeks; weak and unstable responses were seen after 3 weeks. By 4-8 weeks, relative responses to taste stimuli were similar to control responses, but the variability of the responses to sucrose was significantly greater than that in controls. The frequency of responses to the water rinse following taste stimuli, particularly sucrose, was also greater in the regenerated nerves. The abnormal electrophysiological responses to sucrose may be the result of the differential rate of return of fiber types and/or the transduction mechanisms. In some ways, recovery of the peripheral gustatory system after damage to the chorda tympani nerve recapitulates the later stages of taste bud development.
    [Abstract] [Full Text] [Related] [New Search]