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  • Title: Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer.
    Author: Mutter GL, Boynton KA, Faquin WC, Ruiz RE, Jovanovic AS.
    Journal: Cancer Res; 1996 Oct 01; 56(19):4483-6. PubMed ID: 8813144.
    Abstract:
    Progressive microsatellite changes in replication error positive (RER+) endometrium were used to reconstruct evolutionary stages of nonfamilial adenocarcinoma. RER+ putative endometrial precancers (atypical endometrial hyperplasias) progress to RER+ carcinomas, which retain some of the altered microsatellites acquired in earlier precursor stages. The RER+ phenotype may provide a specific marker for early-stage endometrial neoplasms that cannot be resolved by routine histopathology and may be a useful tool to stratify stages in the evolution of RER+ tumors.
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