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  • Title: Hepatotoxicity of N, N-dimethylformamide in rats following intraperitoneal or inhalation routes of administration.
    Author: Roure MB, Lambert AM, Cour C, Bonnet P, Saillenfait AM.
    Journal: J Appl Toxicol; 1996; 16(3):265-7. PubMed ID: 8818869.
    Abstract:
    Male Sprague-Dawley rats were administered a single intraperitoneal injection of N, N-dimethylformamide (DMF, 0.01-1.5 g kg-1) or were exposed for 4 h to DMF vapours (75-900 ppm). The serum activities of the enzymes sorbitol deshydrogenase and glutamate deshydrogenase were used as indicators of liver damage, and were determined at 24, 48 or 72 h post-treatment. Following either route of administration DMF caused concentration-dependent elevations in enzyme activities, the maxima of which occurred later after administration of higher concentrations of DMF than after lower concentrations.
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