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  • Title: [The participation of the renin-angiotensin-aldosterone system in the pathogenesis of acute kidney failure in endotoxemia].
    Author: Krishtal' NV, Frolov AF, Kukharchuk AL.
    Journal: Lik Sprava; 1995; (3-4):92-4. PubMed ID: 8819932.
    Abstract:
    It was found in acute experiments on white rats that injection of Salmonella typhimurium lipopolysaccharide activates renin-angiotensin-aldosterone system (RAAS) and causes oligohydruria form of acute renal failure (ARF). Enalapril, angiotensin-converting enzyme, being injected simultaneously with endotoxin, increases diuresis, glomerular filtration rate, electrolytes excretion and reabsorption by proximal tubules, decreases proteinuria and blood nitrogen-down to the normal. Thus, RAAS takes part in endotoxemia ARF induction and enalapril has protective effect.
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