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  • Title: Down-regulation of Na channel expression by A23187 in N1E-115 neuroblastoma cells.
    Author: Hirsh JK, Quandt FN.
    Journal: Brain Res; 1996 Jan 15; 706(2):343-6. PubMed ID: 8822380.
    Abstract:
    Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal Ca may therefore control excitability by independent regulation of Na and K channel mRNA abundance in neurons.
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