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  • Title: [Effect of colchicine on the morphogenesis and ultrastruct of Acetabularia mediterranea].
    Author: Betina MI, Salamakha OV, Tikhomirova LA, Ianushevich IV.
    Journal: Ontogenez; 1977; 8(1):62-7. PubMed ID: 882244.
    Abstract:
    The effect of colchicine on morphogenesis of the regenerating nuclear fragments of Acetabularia mediterranea has been studied. Colchicine was shown to inhibit the formation of caps. The algae are most sensitive to colchicine at the early stages of regeneration. The breakdown of microtubules in the perinuclear cytoplasm of regenerating algae under the effect of colchicine was found under the electron microscopy. The breakdown of microtubules in this zone appears not to disturb the transport of morphogenetical substances in the apical cell part. Colchicine inhibits the morphogenesis, apparently, at the expense of protein inactivation in the zone of growth.
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