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  • Title: HLA-B27 subtypes in Japanese with seronegative spondyloarthropathies and healthy controls.
    Author: Yamaguchi A, Ogawa A, Tsuchiya N, Shiota M, Mitsui H, Tokunaga K, Tadokoro K, Juji T, Ito K.
    Journal: J Rheumatol; 1996 Jul; 23(7):1189-93. PubMed ID: 8823691.
    Abstract:
    OBJECTIVE: To determine HLA-B27 subtype frequencies in Japanese patients with seronegative spondyloarthropathies (SpA) and healthy controls. METHODS: We determined HLA-B27 subtypes of 20 Japanese patients with ankylosing spondylitis and one with Reiter's syndrome, and 11 healthy Japanese individuals using a polymerase chain reaction sequence specific oligonucleotide hybridization method specifically designed for the discrimination of B*2701-09. RESULTS: 14 of 21 (67%) patients and 9 of 11 (82%) controls were typed as B*2704. The remainder were B*2705. CONCLUSION: HLA-B*2704 and B*2705 are present in the Japanese population, the former being the predominant subtype of HLA-B27. Both subtypes are associated with SpA.
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