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Title: The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. Author: Siede W, Allen JB, Elledge SJ, Friedberg EC. Journal: J Bacteriol; 1996 Oct; 178(19):5841-3. PubMed ID: 8824640. Abstract: The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.[Abstract] [Full Text] [Related] [New Search]