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  • Title: Localisation of a new gene for non-specific mental retardation to Xq22-q26 (MRX35).
    Author: Gu XX, Decorte R, Marynen P, Fryns JP, Cassiman JJ, Raeymaekers P.
    Journal: J Med Genet; 1996 Jan; 33(1):52-5. PubMed ID: 8825049.
    Abstract:
    Non-specific mental retardation (MR) is a condition in which MR appears to be the only consistent manifestation. The X linked form (MRX) is genetically heterogeneous. We report clinical, cytogenetic, and linkage data on a family with X linked non-specific MR. Two point and multi-point linkage analysis with 18 polymorphic markers, covering the entire chromosome, showed close linkage to DXS1001 and DXS425 with a maximal lod score of 2.41 at 0% recombination. DXS178 and the gene for hypoxanthine phosphoribosyl-transferase (HPRT), located in Xq22 and Xq26 respectively, flank the mutation. All other chromosomal regions could be excluded with odds of at least 100:1. To our knowledge there is currently no other non-specific MR gene mapped to this region. Therefore, the gene causing MR in this family can be considered to be a new, independent MRX locus (MRX35).
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