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  • Title: Low molecular weight copper-binding protein in the liver of rats given a single and repeated injections of copper.
    Author: Suzuki-Kurasaki M, Kurasaki M, Kojima Y.
    Journal: Res Commun Mol Pathol Pharmacol; 1996 Jun; 92(3):299-314. PubMed ID: 8827828.
    Abstract:
    Whether Cu-metallothionein is the sole low molecular weight Cu-binding protein induced in Cu-loaded rat tissues or not is hotly debated, because several investigators reported that Cu-metallothionein did not exist and other Cu-binding proteins were induced in the Cu-loaded rat liver. Investigation by using rats given a single and repeated injections of Cu led us to settle the problem. Cu-metallothionein was identified in the liver of both groups of rats by the purification procedure established in this study. Moreover in the final purification step of Cu-metallothionein, an additional unknown protein which did not belong to the metallothionein group was found only in the rats given repeated Cu injections, and not in the rats given a single Cu injection. The confusion on Cu-metallothionein and other Cu-binding proteins was shown to be caused by inadequate purification of Cu-metallothionein.
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