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  • Title: Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.
    Author: Albert ED, Rittner C, Scholz S, Kuntz B, Mickey MR.
    Journal: Scand J Immunol; 1977; 6(5):459-64. PubMed ID: 882850.
    Abstract:
    The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters, and chi-square values were determined both from the genotype and from the phenotype data. Although the HLA-B,Bf associations involve antigens that are also present in the highly associated A,B and B,D haplotypes of the Caucasian population, there was--with the possible exception of HLA-A3,B7,Bf-S--no significant three-point association for HLA-A,B,Bf.
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