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  • Title: Cyproheptadine treatment in neuroleptic-induced akathisia.
    Author: Weiss D, Aizenberg D, Hermesh H, Zemishlany Z, Munitz H, Radwan M, Weizman A.
    Journal: Br J Psychiatry; 1995 Oct; 167(4):483-6. PubMed ID: 8829717.
    Abstract:
    BACKGROUND: Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia. METHOD: In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. RESULTS: All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. CONCLUSIONS: Cyproheptadine may be useful in neuroleptic-induced akathisia.
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