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  • Title: Galactosamine alters glucose regulation in ten-day-old rats treated with a low dose of endotoxin.
    Author: Topaloglu AK, Goto M, Ravindranath T, Zeller WP.
    Journal: Res Commun Mol Pathol Pharmacol; 1996 Mar; 91(3):297-302. PubMed ID: 8829769.
    Abstract:
    Hypoglycemia develops rapidly during septic shock and is a common and life-threatening problem in the human newborn. In adult animals, galactosamine alter glucose metabolism and increases mortality of endotoxic shock. Galactosamine may alter tissue glucose uptake and induce hypoglycemia in ten-day-old rats. The present study showed that galactosamine induced hypoglycemia and a high mortality without an increase in plasma insulin concentration in ten-day-old rats treated with a low dose of endotoxin. Galactosamine decreased tissue glucose uptake in endotoxin-treated animals. Hypoglycemia induced by galactosamine could be due to decreased gluconeogenesis.
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