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  • Title: Beta 2-receptor density on mononuclear blood cells in patients suffering from neuroleptic-induced akathisia (NIA).
    Author: Botschev C, Bondy B, Hofmann M, Kircher T, Müller-Spahn F.
    Journal: Biol Psychiatry; 1996 Aug 01; 40(3):203-7. PubMed ID: 8830953.
    Abstract:
    The effectiveness of beta-blockers in the treatment of neuroleptic-induced akathisia (NIA) suggests that beta-adrenergic overactivity is involved in the manifestation of NIA. As an approach to understanding this postulated overactivity, we investigated the beta 2-receptor density on mononuclear blood cells in 21 patients suffering from NIA as well as in 12 patients without NIA. The beta 2-receptor density in NIA-positive patients was significantly higher than that in NIA-negative patients (t = 2.84; p = .008). The NIA-positive patients were treated with 20 mg propranolol t.i.d. for 5 days. The beta 2-receptor density in treatment responders did not differ significantly from that in non-responders. Our results indicate that beta 2-receptors on mononuclear cells in patients with NIA may be of a certain degree of importance. With the prerequisites of replicability as well as correlation of this parameter with therapeutic success of beta-blockers, it may be considered as a predictor for treatment response.
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