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  • Title: [Three-phase dynamic helical CT for hepatocellular carcinoma: optimal scanning protocol].
    Author: Shimizu T, Aratake K, Misaki T, Yamamoto K, Tanaka Y, Nishigaki H, Uesugi Y, Matsui R, Sueyoshi K, Kawai T, Narabayashi I.
    Journal: Nihon Igaku Hoshasen Gakkai Zasshi; 1996 Aug; 56(9):621-4. PubMed ID: 8831216.
    Abstract:
    To assess the optimal scanning protocol for three-phase dynamic helical CT, 20 patients were examined according to the following 4 methods (5 cases each) : (1) 100 ml Iopamidol (300 mgI/ml), at a rate of 2 ml/sec ; (2) 120 ml,3 ml/sec, (3) 150 ml, 3 ml/sec ; (4) biphasic method, initial 100 ml, 3.3 ml/sec ; remaining 50 ml, 1.6 ml/sec. Assessment of the time-density curve of the aorta, and the liver parenchyma, indicated that protocol (4) was superior to the others. Using protocol (4), 32 patients (62 nodules) with hepatocellular carcinoma underwent three-phase scanning, consisting of early, late, and delayed phases. Out of 61 nodules, 43 nodules were detected as high density areas in the early phase, 7 nodules as low density areas only in the late phase, and 3 nodules as low density areas only in the delayed phase. Compared with MRI, three-phase dynamic helical CT demonstrated numerous nodules, especially those less than 10 mm in diameter, and, therefore, was useful for the detection of hepatocellular carcinoma.
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