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  • Title: Unexplained macrocytosis in elderly patients.
    Author: Mahmoud MY, Lugon M, Anderson CC.
    Journal: Age Ageing; 1996 Jul; 25(4):310-2. PubMed ID: 8831877.
    Abstract:
    One hundred and twenty-four patients over the age of 75 years were assessed for the cause of their macrocytosis (MCV > 95 fl). A definitive diagnosis was reached in 75/124 (60%) by non-invasive techniques. The remainder underwent a bone marrow biopsy yielding a definitive diagnosis in a further six patients who had an identifiable myelodysplastic syndrome (MDS). A high proportion of the remainder had morphological abnormalities which fitted with no recognized pathological entity. It is suggested that these may represent MDS in evolution.
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