These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of theophylline on ventilatory roll-off during hypoxia in goats.
    Author: Gershan WM, Forster HV, Lowry TF, Garber AK.
    Journal: Respir Physiol; 1996 Feb; 103(2):157-64. PubMed ID: 8833547.
    Abstract:
    The increase in pulmonary ventilation (VE) during the first minutes of hypoxia is not sustained as after several minutes VE decreases or "rolls-off" toward control levels. We hypothesized that intravenous infusion of theophylline, by blocking the central inhibitory effects on breathing of adenosine, would attenuate the hypoxic VE roll-off. Twelve unanesthetized adult goats were exposed for 20 min to a 12% O2-88% N2 gas mixture. In some studies,theophylline was infused intravenously (IV) for 20 min before and during the hypoxia. The highest infusion rate of 6.0--8.0 mg/min was sufficient to totally prevent the arterial hypertension and bradycardia that occurred with IV infusion of 4 mg min (-1) of adenosine. Nine of the 12 goats demonstrated VE roll-off without the theophylline infusion. In goats that demonstrated VE roll-off without theophylline, a significant (P < 0.05) VE roll-off was observed even at the highest theophylline infusion rate. We therefore conclude that the VE roll-off during hypoxia is not primarily or critically mediated by adenosine in awake, adult goats.
    [Abstract] [Full Text] [Related] [New Search]