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  • Title: Suspected neuroleptic malignant syndrome in a patient receiving clozapine.
    Author: Ganelin L, Lichtenberg PS, Marcus EL, Munter RG.
    Journal: Ann Pharmacother; 1996 Mar; 30(3):248-50. PubMed ID: 8833560.
    Abstract:
    OBJECTIVE: To report a case of suspected neuroleptic malignant syndrome (NMS) associated with clozapine therapy. CASE SUMMARY: A 42-year-old schizophrenic man treated with clozapine developed a temperature of 39.5 degrees C, diaphoresis, tachycardia, rigidity, and leukocytosis. His serum creatine kinase concentration was 25 000 U/L. A diagnosis of NMS was made. He was treated with bromocriptine and supportive therapy, and recovered within a week. DISCUSSION: Despite earlier expectations that clozapine, with a pharmacologic profile differing from that of other antipsychotic medications, might not cause NMS, NMS remains the most likely diagnosis in this case. CONCLUSIONS: NMS may be a possible complication of clozapine therapy.
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