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  • Title: Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization.
    Author: Cheville JC, Bromley C, Argenyi ZB.
    Journal: J Cutan Pathol; 1995 Dec; 22(6):546-50. PubMed ID: 8835173.
    Abstract:
    Keratoacanthoma (KA) is generally considered to be a clinically and histologically distinct entity, but it often remains difficult to separate from well-differentiated squamous cell carcinoma (WDSCC). Recently, trisomy 7 has been identified in squamous cell carcinoma of the skin. In this study, we examined classical KA (n = 6), WDSCC (n = 7) and squamous cell carcinoma with KA-like features (SCC-KA) (n = 8) for trisomy 7 by fluorescence in-situ hybridization (FISH) to determine if this chromosomal abnormality is unique to squamous lesions diagnosed as WDSCC, or shared by both KA and SCC. In addition, the pertinent clinical-histopathologic findings were summarized. Trisomy 7 was identified in one KA, one SCC-KA and two WDSCC. This study demonstrates that there is a chromosomal abnormality shared by KA and SCC, providing further evidence that KA is most likely a form of SCC. Further studies are required to determine if trisomy 7 in these lesions is of prognostic significance.
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