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  • Title: Effect of ticarcillin and ticarcillin/clavulanic acid on the in-vitro activity of human granulocytes against beta-lactamase-producing Klebsiella pneumoniae.
    Author: Cuffini AM, de Renzi G, Tullio V, Paizis G, Carlone NA.
    Journal: Int J Tissue React; 1995; 17(5-6):199-203. PubMed ID: 8835630.
    Abstract:
    Clavulanic acid is an effective inhibitor of a broad range of clinically important beta-lactamases and its combination with some beta-lactam antibiotics such as ticarcillin has been shown to extend the inhibition spectrum of the beta-lactams. The activity of ticarcillin, both alone and in combination with clavulanic acid, upon PMN phagocytosis and bactericidal activity towards Klebsiella pneumoniae was investigated. The results indicate that a combination of ticarcillin with clavulanic acid is more active than ticarcillin alone against a beta-lactamase-producing strain of K. pneumoniae, and hence may significantly increase the bacterial vulnerability to phagocyte functions.
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