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  • Title: Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum.
    Author: Colwell CS, Altemus KL, Levine MS.
    Journal: Brain Res; 1996 Jul 08; 726(1-2):223-6. PubMed ID: 8836564.
    Abstract:
    The present study was designed to compare the protective consequences of activation of metabotropic glutamate receptors (mGluRs) on N-methyl-D-aspartate (NMDA)- and kainic acid (KA)-induced excitotoxicity in vivo. Pretreatment with the mGluR agonist ISR,3RS-1-aminocyclo-pentane-1,3-dicarboxylic acid (tACPD) limited the anatomical and behavioral consequences of the intrastriatal administration of the NMDA agonist quinolinic acid (QA). In contrast, pretreatment with tACPD did not alter the effects of intrastriatal injection of KA.
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