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  • Title: Comparison of magnetic resonance angiography and conventional angiography in sickle cell disease: clinical significance and reliability.
    Author: Kandeel AY, Zimmerman RA, Ohene-Frempong K.
    Journal: Neuroradiology; 1996 Jul; 38(5):409-16. PubMed ID: 8837081.
    Abstract:
    We retrospectively reviewed the medical records and conventional angiograms of 21 patients with known sickle cell disease, who underwent a total of 50 magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) studies. MRA and conventional angiography were assessed separately for evidence of stenosis or occlusion. Follow up MRI/MRA studies were also assessed for evidence of progression, regression or stability of the disease in these patients. In the carotid circulation, MRA made the correct diagnosis in 85% of the vessels evaluated with a sensitivity of 80.5% and a specificity of 94%. MRA was also found to show evidence of disease progression, more often than did MRI or the clinical condition of the patients.
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