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  • Title: [Selective permeability of the glomerular filtration barrier in man].
    Author: Petitjean P, Chantrel F, Hannedouche T.
    Journal: Nephrologie; 1996; 17(2):113-6. PubMed ID: 8838757.
    Abstract:
    Glomerular ultrafiltration of macromolecules is a biophysical process sharing both a diffusive and a convective component, governed by glomerular hemodynamics, through a composite structure, the glomerular filtration barrier. Studies of the fractional clearance of macromolecules have showed that transcapillary filtration of macromolecules is hindered by size, electrostatic charge and to a lesser degree by spatial conformation. Several modelizations of ultrafiltration have been developped to quantify the respective role of glomerular hemodynamic and/or membrane structural alternations as found in glomerular diseases.
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