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  • Title: Overexpression of calcium/calmodulin-dependent protein kinase II in insulinoma cells by use of a retroviral vector.
    Author: Möhlig M, Mayer P, Horn PA, Schatz H, Pfeiffer A.
    Journal: Exp Clin Endocrinol Diabetes; 1995; 103 Suppl 2():71-3. PubMed ID: 8839257.
    Abstract:
    The manner in which increasing intracellular calcium levels lead to insulin exocytosis is not known. Possibly the signal is mediated by activation of calcium/calmodulin-dependent protein kinase II (CaM Kin II). In this work the establishment of an insulinoma cell line stably overexpressing CaM Kinase II subtype delta 2 by an ecotropic retroviral transduction system is described.
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